Ivermectin: Multifaceted drug with potential in oncology

Anti Cancer February 5, 2025

The Ivermectin, being avermectin deviation, one of the widely accepted anti parasitic drugs applied for humans and in animal care. Till today this medicine has been safely administered to 200+ million individuals globally. With the discovery in the decade of 1970s, this formulation has been extracted from a single microbe. And the research on this antiparasitic drug was performed at Kitasato Institute, situated in the capital city of Japan, Tokyo.

History of Ivermectin as anti-parasitic drug

  • Originated as an animal care drug, it has been found to arrest the array of both internal as well as external parasites, existing in commercial & even domestic livestock. Since then, it has become the go-to formula to handle devastating as well as disfiguring parasitic infections, utilized as a sole formula within the campaigns for eliminating parasitic disorders worldwide.
  • Owing to its widespread application in human and animal care, it has garnered Nobel Prize, in the year 2015.
  • Although several chemotherapeutic formulations exist, rendering as a first line of cancer treatment. During the initial period, satisfactory results are attained. However, at the later stage, the efficacy of the chemotherapeutic agent reduces with time.

Researches on potential of Ivermectin for cancer treatment

  • Owing to the imperativeness for coming up with effective anticancer therapy, this same drug, Ivermectin has been investigated as a potential for inhibiting the process of cancer metastasis.
  • Several research studies carried out for ascertaining the ivermectin efficacy in cancer cures. The reports indicated that this animal care product has efficiency in the inhibition of cellular proliferation, thereby demonstrating a potential role in arresting its growth.
  • In one of the studies that came up in NPJ cancer journal, this anti-parasite medicine, through the combination of the checkpoint inhibitor is found to be effective in triple-negative breast cancer within the preclinical research.
  • Relying on the basis of the novel dual mechanism action, its anticancer & immunomodulatory impact, this formula can potentiate, cancer cure activity and provide a safe & cheap way, while roughly at a cost of around $ 20/ dosage, making it accessible with attainability of treatment for cancer patients globally.

Case studies on Ivermectin cancer treatment

Combination of the drugs after the addition of the few dosages in lower amount of ivermectin has demonstrated a positive impact in cancer patients

Case study 1

A woman aged 69 years, having breast cancer, has undergone a surgical procedure. However, conventional therapies with time have demonstrated fewer positive impacts,

  • Along with the adversaries intolerable for the patient. But when she was given a Cocktail of dichloroacetate, omeprazole, and tamoxifen, at the same time 12 mg dosage of ivermectin every day, there was stabilization of the pleural effusion and reduction within tumor marker from 12.9 to as low as 7.3.

Case study 2

One male aged 54 years, has lung adenocarcinoma disease. Chemotherapy was found effective during the early stage, but then metastasis started to exist.

There is a combination of dichloroacetate, omeprazole, and ivermectin (12 mg)/ day for a week administered to the patient. There is improvement in the symptoms and by doubling the Ivermectin dosage for a number of weeks, the patient gets relieved from symptoms.

Ivermectin dosages for different categories of cancer cure

Cancer Type Tumour Cell Lining Number of Days Treatment Dosage (mg/kg)
Murine Leukaemia MDAY-2 10 3, 5, 6 (ip)
Human Glioblastoma OCI-AML2, U87, T98G 21 40
Breast Cancer MDA-MB-231-GFP 10 2.4 (i.p)
Human Glioma U87MG 42 3, 10 (i.t)
Human Colon Cancer LDL1, CC14, HT29 21 10 (i.p)

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