The Ivermectin, being avermectin deviation, one of the widely accepted anti parasitic drugs applied for humans and in animal care. Till today this medicine has been safely administered to 200+ million individuals globally. With the discovery in the decade of 1970s, this formulation has been extracted from a single microbe. And the research on this antiparasitic drug was performed at Kitasato Institute, situated in the capital city of Japan, Tokyo.

History of Ivermectin as anti-parasitic drug

• Originated as an animal care drug, it has been found to arrest the array of both internal as well as external parasites, existing in commercial & even domestic livestock. Since then, it has become the go-to formula to handle devastating as well as disfiguring parasitic infections, utilized as a sole formula within the campaigns for eliminating parasitic disorders worldwide.
• Owing to its widespread application in human and animal care, it has garnered Nobel Prize, in the year 2015.
• Although several chemotherapeutic formulations exist, rendering as a first line of cancer treatment. During the initial period, satisfactory results are attained. However, at the later stage, the efficacy of the chemotherapeutic agent reduces with time.

Researches on potential of Ivermectin for cancer treatment

• Owing to the imperativeness for coming up with effective anticancer therapy, this same drug, Ivermectin has been investigated as a potential for inhibiting the process of cancer metastasis.
• Several research studies carried out for ascertaining the ivermectin efficacy in cancer cures. The reports indicated that this animal care product has efficiency in the inhibition of cellular proliferation, thereby demonstrating a potential role in arresting its growth.
• In one of the studies that came up in NPJ cancer journal, this anti-parasite medicine, through the combination of the checkpoint inhibitor is found to be effective in triple-negative breast cancer within the preclinical research.
• Relying on the basis of the novel dual mechanism action, its anticancer & immunomodulatory impact, this formula can potentiate, cancer cure activity and provide a safe & cheap way, while roughly at a cost of around $ 20/ dosage, making it accessible with attainability of treatment for cancer patients globally.

Case studies on Ivermectin cancer treatment

Combination of the drugs after the addition of the few dosages in lower amount of ivermectin has demonstrated a positive impact in cancer patients

Case study 1

A woman aged 69 years, having breast cancer, has undergone a surgical procedure. However, conventional therapies with time have demonstrated fewer positive impacts,

• Along with the adversaries intolerable for the patient. But when she was given a Cocktail of dichloroacetate, omeprazole, and tamoxifen, at the same time 12 mg dosage of ivermectin every day, there was stabilization of the pleural effusion and reduction within tumor marker from 12.9 to as low as 7.3.

Case study 2

One male aged 54 years, has lung adenocarcinoma disease. Chemotherapy was found effective during the early stage, but then metastasis started to exist.

There is a combination of dichloroacetate, omeprazole, and ivermectin (12 mg)/ day for a week administered to the patient. There is improvement in the symptoms and by doubling the Ivermectin dosage for a number of weeks, the patient gets relieved from symptoms.

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Parasitic infections are holding the responsibility for the high level of the morbidity along with the mortality globally. Certain parasites have high adaptability to residing within the intestinal lumen. And there are many others that are prevalent within organism blood or tissues in some other body parts.

The cancer disease is holding the accountability for around one death within 6th of the people. Many people are actually putting efforts into finding complementary and alternative therapeutic procedures for cancer. Ivermectin, primarily used for animal care demonstrates the utmost potential for providing support to cancer care.

Ivermectin for animal cure

• Ivermectin in the form of an oral drug, cream, or gel holds anti-parasitic activity and is meant for curing internal as well as external parasites within the livestock.
• Being an antihelminth, it exhibits the inhibitory action of the nervous system, exhibiting the deworming impact.

Ivermectin for cancer treatment

• The growing studies has already repurposed the animal care drug for the cancer therapeutic procedure.
• Ivermectin, primarily well known for animal cures in treating parasitic infection, exhibits the action mechanism for impeding the growth of the cancer cells as well as survival.

This animal cure product has the inherent capability of modulating the immune responsiveness. And thus, it complements the immunotherapeutic measures for cancer treatment.

Ivermectin protocol for parasitic infection treatment

Dosage for Onchocerciasis

0.15 mg per Kg administered once a year

Dosage recommendations based on body weight

• 15- 25 Kg- concentration of 3 mg administered orally once
• 26-44 Kg- concentration of 6 mg administered orally once
• 45- 64 Kg- concentration of 9 mg administered orally once
• 65- 84 Kg- concentration of 12 mg administered orally once

Ivermectin protocol for Strongyloidiasis

0.2 mg per Kg administered orally once

Dosage recommendation on the basis of body weight

• 15-24 Kg- 3 mg administered orally single time
• 25- 35 Kg- 6 mg administered orally single time
• 36- 50 kg- 9 mg administered orally single time
• 51- 65 Kg-12 mg administered orally single time

Dosage instructions for Ascariasis

0.2 mg per Kg rendered orally once

Recommended dosage for filariasis

0.2 mg per Kg administered orally once

Administration of the dosage for Bancroftian filariasis

0.4 mg per Kg administered through oral route once in a year

Dosage instructions for scabies

0.2 mg/ Kg administered orally and repeated once in 15 days

Ivermectin protocol for cancer treatment

• Tumor cells of low-grade

The dosage instruction is 0.5 mg per Kg, with the frequency of thrice in a week

• Tumor cells of intermediate-grade

The dosage recommendation is 1mg per Kg with a frequency of three times a week

• Tumor cell of higher grade level

The dosage is varying within the range of 1 mg/ Kg to 2 mg per Kg per day

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